Bicarbonate transport

Across TCGA cell cohorts, RNA activity of the Bicarbonate transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSO, BBOF1, and VIPAS39, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bicarbonate transport activity versus CTSO in BREAST (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CTSO →	+0.700	+0.782	.004	.005	3	4
LIVER	BBOF1 →	+1.392	+1.903	<.001	<.001	3	4
LIVER	VIPAS39 →	+0.702	+1.903	.005	<.001	3	4
SKIN	CDC37L1 →	+0.880	+1.337	<.001	<.001	3	4
SKIN	LAMA5 →	+1.896	+1.300	.003	<.001	3	4
LUNG_NSCLC_LUAD	CXXC4 →	+0.677	+0.883	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015701 vs CTSO — BREAST

Explore this scatter interactively →