Quaternary ammonium group transport

Across TCGA patient cohorts, RNA activity of the Quaternary ammonium group transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DENND2D, TPRN_S241, and TTC39A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Quaternary ammonium group transport activity versus DENND2D in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DENND2D →	+0.337	+0.042	.004	.004	3	8
BRCA	TPRN_S241 →	+0.473	+0.033	<.001	<.001	3	7
BRCA	TTC39A →	+0.490	+0.035	<.001	<.001	3	7
BRCA	PLOD1 →	-0.519	-0.050	<.001	<.001	3	7
PDAC	MAOA →	+0.514	+0.030	<.001	.006	3	7
BRCA	STARD10 →	+0.757	+0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015697 vs DENND2D — BRCA

Explore this scatter interactively →