Quaternary ammonium group transport

Across TCGA patient cohorts, RNA activity of the Quaternary ammonium group transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSIR, GIMAP7, and SATB1-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Quaternary ammonium group transport activity versus VSIR in LUAD (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VSIR →	-0.428	-0.579	.002	.002	3	4
BRCA	GIMAP7 →	-0.703	-0.547	.008	.003	3	4
BRCA	SATB1-AS1 →	-0.374	-0.784	<.001	<.001	3	4
OV	PDE1C →	-0.269	-0.298	.003	.004	3	3
OV	EPHB1 →	-0.965	-0.408	<.001	<.001	3	3
OV	TRBV13 →	-0.570	-0.358	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015697 vs VSIR — LUAD

Explore this scatter interactively →