Magnesium ion transport

Across TCGA patient cohorts, RNA activity of the Magnesium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, STXBP1, and SORBS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Magnesium ion transport activity versus SYNPO in CCRCC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SYNPO →	+0.335	+0.029	.001	.009	3	5
GBM	STXBP1 →	+0.562	+0.056	<.001	.001	3	5
CCRCC	SORBS1 →	+0.477	+0.047	.004	.001	3	5
GBM	KANK2_S540 →	+0.363	+0.057	.005	.001	3	5
GBM	POLDIP2 →	-0.275	-0.087	<.001	<.001	3	5
COAD	SLIRP →	-0.232	-0.027	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015693 vs SYNPO — CCRCC

Explore this scatter interactively →