Magnesium ion transport

Across TCGA patient cohorts, RNA activity of the Magnesium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JADE2, MDM1, and OLFML2B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Magnesium ion transport activity versus JADE2 in COAD (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JADE2 →	-0.438	-0.403	.004	.009	3	3
HNSC	MDM1 →	-0.770	-0.649	<.001	<.001	3	3
HNSC	OLFML2B →	-0.660	-0.622	.009	.001	3	3
BRCA	BAHCC1 →	-0.492	-0.510	.005	<.001	3	3
PDAC	RNASE8 →	-0.337	-0.746	<.001	.002	3	3
PDAC	CTDSP2 →	-0.259	-0.633	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015693 vs JADE2 — COAD

Explore this scatter interactively →