Magnesium ion transport

Across TCGA cell cohorts, RNA activity of the Magnesium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCMR, CPEB3, and ZNF621, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FCMR grouped by Magnesium ion transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FCMR →	-3.674	-1.506	.001	.003	3	4
PANCREAS	CPEB3 →	+0.300	+0.888	.006	.003	3	4
SOFT_TISSUE	ZNF621 →	+0.918	+1.129	<.001	.006	3	4
BREAST	BEST4 →	-0.213	-0.749	.007	.006	3	4
BLOOD_Myeloma	CTNNBL1 →	+0.732	+1.635	.002	<.001	3	3
BLOOD_Myeloma	SUOX →	+0.929	+1.846	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FCMR by Magnesium ion transport activity — BLOOD_Myeloma

Explore this box plot interactively →