Magnesium ion transport

Across TCGA cell cohorts, RNA activity of the Magnesium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TM9SF2, GRM3, and ESYT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Magnesium ion transport activity versus TM9SF2 in STOMACH (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TM9SF2 →	+1.313	+1.451	<.001	.005	3	4
OESOPHAGUS	GRM3 →	+0.047	+0.894	.009	.004	3	3
OVARY	ESYT2 →	+1.084	+1.145	<.001	.001	3	3
OVARY	PHF20L1 →	+0.980	+0.737	.003	.009	3	3
OVARY	OGT →	+0.933	+0.931	.004	<.001	3	3
OVARY	ATP5ME →	-0.891	-1.242	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015693 vs TM9SF2 — STOMACH

Explore this scatter interactively →