Copper ion import

Across TCGA patient cohorts, RNA activity of the Copper ion import pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF660, CHST13, and CRTC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion import activity versus ZNF660 in HNSC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF660 →	-0.541	-0.488	.003	.006	3	4
LSCC	CHST13 →	-0.387	-0.229	.001	.002	3	3
CCRCC	CRTC3 →	-0.234	-0.541	.009	<.001	3	3
CCRCC	PLCD3 →	-0.662	-0.513	<.001	<.001	3	3
PDAC	RASSF2 →	-0.486	-0.300	<.001	<.001	3	3
PDAC	SLC5A10 →	-0.121	-0.238	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015677 vs ZNF660 — HNSC

Explore this scatter interactively →