Copper ion import

Across TCGA cell cohorts, RNA activity of the Copper ion import pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP7B, STEAP3, and SLC31A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP7B grouped by Copper ion import-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATP7B →	-0.313	-0.741	<.001	<.001	3	8
SKIN	STEAP3 →	-0.287	-1.876	<.001	<.001	3	5
LUNG_NSCLC_LUAD	SLC31A1 →	-0.151	-0.933	.001	<.001	3	5
OVARY	NTSR1 →	-0.117	-0.796	<.001	.001	3	4
SKIN	PRKCG →	-0.163	-1.090	<.001	.008	3	4
BREAST	STEAP2 →	-0.278	-1.066	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP7B by Copper ion import activity — BREAST

Explore this box plot interactively →