Copper ion import

Across TCGA cell cohorts, RNA activity of the Copper ion import pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP10, CMC2, and KLHDC4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion import activity versus USP10 in BREAST (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	USP10 →	+1.253	+1.820	<.001	<.001	3	3
BREAST	CMC2 →	+1.392	+1.820	.002	<.001	3	2
BREAST	KLHDC4 →	+1.277	+1.820	<.001	<.001	3	2
BREAST	SC5D →	+1.331	+1.820	.002	<.001	3	2
BREAST	ARL6 →	+0.853	+1.846	.007	<.001	3	2
BREAST	MARK1 →	-2.020	-1.834	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015677 vs USP10 — BREAST

Explore this scatter interactively →