Oxygen transport

Across TCGA patient cohorts, RNA activity of the Oxygen transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC4A1, SPTB, and EPB42, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxygen transport activity versus SLC4A1 in PDAC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC4A1 →	+0.852	+0.142	<.001	<.001	3	9
BRCA	SPTB →	+0.710	+0.070	<.001	<.001	3	9
BRCA	EPB42 →	+0.720	+0.072	<.001	<.001	3	9
OV	ANK1 →	+0.965	+0.107	.001	<.001	3	9
PDAC	SLC4A1_S356 →	+1.809	+0.213	<.001	<.001	3	8
GBM	FCN3 →	+0.767	+0.141	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015671 vs SLC4A1 — PDAC

Explore this scatter interactively →