Oxygen transport

Across TCGA patient cohorts, RNA activity of the Oxygen transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBA2, HBB, and PPBP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxygen transport activity versus HBA2 in GBM (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HBA2 →	+1.710	+0.346	<.001	<.001	3	8
OV	HBB →	+1.911	+0.496	<.001	.002	3	8
GBM	PPBP →	+1.198	+0.273	<.001	<.001	3	7
GBM	HBA1 →	+1.650	+0.355	<.001	<.001	3	7
GBM	PF4 →	+0.875	+0.256	<.001	<.001	3	7
GBM	S100A12 →	+0.869	+0.205	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015671 vs HBA2 — GBM

Explore this scatter interactively →