Oxygen transport

Across TCGA cell cohorts, RNA activity of the Oxygen transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO36, ALG6, and NFS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO36 grouped by Oxygen transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FBXO36 →	+0.457	+0.925	.001	.004	3	4
SOFT_TISSUE	ALG6 →	-0.547	-1.028	.009	.008	3	4
KIDNEY	NFS1 →	+0.594	+0.814	.002	.008	3	4
BLOOD_Leukemia	GTF2I →	+1.092	+1.116	<.001	<.001	3	3
CNS	PPM1L →	-0.685	-0.765	.001	.003	3	3
CNS	ADAMTSL5 →	+1.404	+0.962	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO36 by Oxygen transport activity — BLOOD_Leukemia

Explore this box plot interactively →