Oxygen transport

Across TCGA cell cohorts, RNA activity of the Oxygen transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAR2, GABARAPL1, and RIN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxygen transport activity versus FAR2 in STOMACH (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAR2 →	-3.335	-0.484	.009	.003	3	4
SKIN	GABARAPL1 →	+1.253	+0.511	.001	.001	3	3
BLOOD_Leukemia	RIN1 →	-1.607	-0.377	.003	.007	3	3
BLOOD_Leukemia	MFSD2A →	-2.051	-0.540	.004	.001	3	3
OVARY	NOVA1 →	+1.738	+0.377	.003	.003	3	3
OVARY	H4C5 →	+1.453	+0.565	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015671 vs FAR2 — STOMACH

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