Carbon dioxide transport

Across TCGA patient cohorts, RNA activity of the Carbon dioxide transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC4A1, SPTB, and UTP15, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbon dioxide transport activity versus SLC4A1 in CCRCC (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC4A1 →	+0.850	+0.091	.001	.004	3	8
OV	SPTB →	+0.775	+0.096	<.001	.002	3	8
LSCC	UTP15 →	-0.300	-0.143	.001	<.001	3	8
OV	CA3 →	+0.916	+0.124	<.001	<.001	3	8
GBM	ADNP →	-0.400	-0.112	<.001	<.001	3	8
BRCA	EPB41 →	+0.745	+0.126	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015670 vs SLC4A1 — CCRCC

Explore this scatter interactively →