Carbon dioxide transport

Across TCGA patient cohorts, RNA activity of the Carbon dioxide transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBA2, HBB, and HBA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbon dioxide transport activity versus HBA2 in LSCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HBA2 →	+1.580	+0.901	<.001	<.001	3	7
BRCA	HBB →	+2.145	+0.284	<.001	<.001	3	7
GBM	HBA1 →	+1.340	+0.282	<.001	<.001	3	6
GBM	PPBP →	+1.558	+0.381	<.001	<.001	3	6
GBM	PF4 →	+0.632	+0.240	<.001	<.001	3	5
OV	LRPPRC →	-0.328	-0.595	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015670 vs HBA2 — LSCC

Explore this scatter interactively →