Carbon dioxide transport

Across TCGA patient cohorts, RNA activity of the Carbon dioxide transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HBZ, SLC4A1, and SPTB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbon dioxide transport activity versus HBZ in COAD (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HBZ →	+1.286	+0.291	.001	<.001	3	8
CCRCC	SLC4A1 →	+1.365	+0.610	<.001	<.001	3	8
CCRCC	SPTB →	+1.351	+0.658	<.001	<.001	3	8
CCRCC	EPB42 →	+1.255	+0.647	<.001	<.001	3	8
CCRCC	HBD →	+1.374	+0.693	<.001	<.001	3	8
CCRCC	ANK1 →	+1.250	+0.692	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015670 vs HBZ — COAD

Explore this scatter interactively →