Gas transport

Across TCGA patient cohorts, RNA activity of the Gas transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MPHOSPH10, NOL11, and SPTB, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gas transport activity versus MPHOSPH10 in LSCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MPHOSPH10 →	-0.401	-0.112	<.001	<.001	3	9
LSCC	NOL11 →	-0.286	-0.108	.001	<.001	3	9
BRCA	SPTB →	+0.970	+0.066	<.001	.002	3	8
LSCC	TNS2 →	+0.305	+0.122	<.001	<.001	3	8
HNSC	ADNP →	-0.320	-0.130	<.001	<.001	3	8
OV	CSTF3 →	-0.221	-0.062	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015669 vs MPHOSPH10 — LSCC

Explore this scatter interactively →