Gas transport

Across TCGA patient cohorts, RNA activity of the Gas transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBA2, HBB, and PPBP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gas transport activity versus HBA2 in BRCA (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HBA2 →	+1.838	+0.300	<.001	<.001	3	7
GBM	HBB →	+1.495	+0.333	<.001	<.001	3	7
GBM	PPBP →	+0.971	+0.314	<.001	<.001	3	6
GBM	HBA1 →	+1.530	+0.391	<.001	<.001	3	6
GBM	PF4 →	+0.747	+0.303	<.001	<.001	3	6
UCEC	TCIM →	+0.927	+0.209	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015669 vs HBA2 — BRCA

Explore this scatter interactively →