Gas transport

Across TCGA cell cohorts, RNA activity of the Gas transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIPR1, ACTRT3, and SLC2A8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIPR1 grouped by Gas transport-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EIPR1 →	-0.561	-1.608	<.001	<.001	3	4
URINARY_TRACT	ACTRT3 →	+1.102	+1.633	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SLC2A8 →	-1.234	-1.438	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SIK3 →	-0.604	-1.256	.008	.002	3	4
UPPER_AERODIGESTIVE_TRACT	PDGFA →	-1.186	-1.466	.002	<.001	3	4
OVARY	BEST1 →	-1.255	-1.361	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIPR1 by Gas transport activity — URINARY_TRACT

Explore this box plot interactively →