Gas transport

Across TCGA cell cohorts, RNA activity of the Gas transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D23, GUCY1B1, and SF3A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gas transport activity versus TBC1D23 in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TBC1D23 →	+0.785	+0.391	.005	.003	2	4
LUNG_SCLC	GUCY1B1 →	+3.857	+0.301	<.001	.007	3	3
SKIN	SF3A2 →	-0.834	-0.556	.001	<.001	3	3
SKIN	GABARAPL1 →	+1.253	+0.511	.001	.001	3	3
BLOOD_Leukemia	MFSD2A →	-2.051	-0.540	.004	.001	3	3
BLOOD_Leukemia	RIN1 →	-1.607	-0.377	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015669 vs TBC1D23 — BLOOD_Leukemia

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