Positive regulation of smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of smooth muscle cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FPR2, NAPB, and PRKACG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FPR2 grouped by Positive regulation of smooth muscle cell migration-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FPR2 →	-0.395	-0.136	<.001	<.001	3	5
BLOOD_Myeloma	NAPB →	-0.177	-0.084	<.001	.007	3	5
STOMACH	PRKACG →	-0.143	-0.082	.002	.002	3	5
SKIN	ECHDC2 →	-0.170	-0.087	.005	.004	3	4
OVARY	CCNF →	-0.220	-0.108	.001	.005	3	4
OVARY	KIF13B →	+0.170	+0.106	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FPR2 by Positive regulation of smooth muscle cell migration activity — OVARY

Explore this box plot interactively →