Positive regulation of smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR82, RPL17, and DHX30, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smooth muscle cell migration activity versus WDR82 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	WDR82 →	-0.851	-0.217	.004	.004	3	5
LUNG_NSCLC_LUSC	RPL17 →	-1.388	-0.279	.001	.003	3	5
SKIN	DHX30 →	-0.892	-0.304	.005	.001	3	5
OESOPHAGUS	ZNF773 →	-1.294	-0.296	.006	.001	3	4
URINARY_TRACT	PDHB →	-1.056	-0.337	.003	.002	3	4
UPPER_AERODIGESTIVE_TRACT	CYB5RL →	-0.788	-0.267	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014911 vs WDR82 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →