Smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAST4, DCAF7, and ZBTB20, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAST4 grouped by Smooth muscle cell migration-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAST4 →	-1.107	-0.298	<.001	.002	3	5
CNS	DCAF7 →	+0.432	+0.805	<.001	<.001	3	4
OESOPHAGUS	ZBTB20 →	-0.395	-0.636	.007	.009	3	3
URINARY_TRACT	CIART →	+2.765	+0.512	.003	<.001	3	3
BLOOD_Lymphoma	ZNF595 →	+4.527	+0.484	.005	.007	3	3
BLOOD_Lymphoma	PHACTR1 →	-2.787	-0.495	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAST4 by Smooth muscle cell migration activity — LARGE_INTESTINE

Explore this box plot interactively →