Smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Smooth muscle cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUB, SEMA5B, and ANKRD20A3P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUB grouped by Smooth muscle cell migration-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TUB →	+0.307	+1.614	.002	<.001	3	3
KIDNEY	SEMA5B →	-0.366	-1.673	.002	.002	3	3
LARGE_INTESTINE	ANKRD20A3P →	-0.208	-0.313	.005	<.001	3	3
OVARY	GNRHR2 →	+0.267	+1.582	<.001	.001	3	2
OVARY	REC8 →	+0.287	+1.929	.003	<.001	3	2
STOMACH	PLIN1 →	+0.263	+1.882	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUB by Smooth muscle cell migration activity — KIDNEY

Explore this box plot interactively →