Smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INTS5, CCDC12, and NOL11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle cell migration activity versus INTS5 in LUNG_SCLC (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	INTS5 →	-0.539	-0.396	<.001	.009	3	4
BREAST	CCDC12 →	-0.558	-0.672	<.001	.003	3	3
CNS	NOL11 →	-0.377	-0.840	.005	.002	3	3
STOMACH	XIAP →	-1.192	-1.596	.007	.009	3	2
STOMACH	MECP2 →	-0.977	-1.649	<.001	.006	3	2
KIDNEY	PRPF31 →	-0.790	-1.123	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014909 vs INTS5 — LUNG_SCLC

Explore this scatter interactively →