Myotube differentiation involved in skeletal muscle regeneration

Across TCGA patient cohorts, RNA activity of the Myotube differentiation involved in skeletal muscle regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTGFRN, TWF1, and EFR3A_S220, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myotube differentiation involved in skeletal muscle regeneration activity versus PTGFRN in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTGFRN →	+0.396	+0.059	.002	.002	1	8
CCRCC	TWF1 →	+0.174	+0.054	<.001	<.001	3	4
CCRCC	EFR3A_S220 →	+0.391	+0.049	.004	.003	3	4
GBM	CDC42EP3_S108 →	-1.262	-0.087	<.001	.001	3	4
GBM	EGFR_S991 →	+0.501	+0.066	.001	<.001	2	5
LSCC	TRIM29_S21 →	+1.325	+0.064	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014908 vs PTGFRN — BRCA

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