Myotube differentiation involved in skeletal muscle regeneration

Across TCGA cell cohorts, RNA activity of the Myotube differentiation involved in skeletal muscle regeneration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1D, SHARPIN, and MROH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EEF1D grouped by Myotube differentiation involved in skeletal muscle regeneration-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EEF1D →	-1.129	-1.675	.009	.001	3	4
OESOPHAGUS	SHARPIN →	-0.602	-1.623	.008	<.001	3	4
OESOPHAGUS	MROH1 →	-0.943	-1.827	.004	<.001	3	4
OESOPHAGUS	CYHR1 →	-0.852	-1.272	.005	<.001	3	4
CNS	RRNAD1 →	-0.584	-1.022	.001	.005	3	4
KIDNEY	SPX →	-1.701	-1.037	.006	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EEF1D by Myotube differentiation involved in skeletal muscle regeneration activity — OESOPHAGUS

Explore this box plot interactively →