Myotube differentiation involved in skeletal muscle regeneration

Across TCGA cell cohorts, RNA activity of the Myotube differentiation involved in skeletal muscle regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTGFRN, CD9, and PTPN11, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myotube differentiation involved in skeletal muscle regeneration activity versus PTGFRN in LIVER (Pearson r = 0.92).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PTGFRN →	+2.969	+2.041	.008	.001	2	13
LUNG_NSCLC_LUSC	CD9 →	+2.280	+2.386	.003	<.001	3	10
OVARY	PTPN11 →	-1.194	-1.321	<.001	<.001	3	8
URINARY_TRACT	LARP4B →	-1.583	-2.060	.002	<.001	3	6
OVARY	UBXN1 →	-1.616	-1.008	<.001	.004	3	6
OVARY	SNX5 →	-1.862	-1.177	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014908 vs PTGFRN — LIVER

Explore this scatter interactively →