Myoblast fusion involved in skeletal muscle regeneration

Across TCGA patient cohorts, RNA activity of the Myoblast fusion involved in skeletal muscle regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGAV, MMP2, and PTGFRN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast fusion involved in skeletal muscle regeneration activity versus ITGAV in OV (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ITGAV →	+0.632	+0.069	.001	.009	3	6
BRCA	MMP2 →	+0.599	+0.067	<.001	<.001	3	6
CCRCC	PTGFRN →	+0.655	+0.119	<.001	<.001	3	6
BRCA	C1R →	+0.526	+0.076	<.001	<.001	3	5
PDAC	SH3PXD2B →	+0.292	+0.061	.001	<.001	3	5
BRCA	MRC2 →	+0.599	+0.087	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014905 vs ITGAV — OV

Explore this scatter interactively →