Myoblast fusion involved in skeletal muscle regeneration

Across TCGA patient cohorts, RNA activity of the Myoblast fusion involved in skeletal muscle regeneration pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGFRN, FAM162A, and PLPPR4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast fusion involved in skeletal muscle regeneration activity versus PTGFRN in CCRCC (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTGFRN →	+1.259	+0.129	<.001	<.001	3	7
LSCC	FAM162A →	+0.685	+0.081	<.001	.003	3	5
OV	PLPPR4 →	+0.830	+0.071	<.001	.004	3	5
GBM	DCLK1 →	+0.900	+0.049	.001	<.001	3	5
COAD	ZNF436 →	+0.467	+0.053	.001	.008	3	5
PDAC	CSDC2 →	+0.555	+0.132	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014905 vs PTGFRN — CCRCC

Explore this scatter interactively →