Myoblast fusion involved in skeletal muscle regeneration

Across TCGA cell cohorts, RNA activity of the Myoblast fusion involved in skeletal muscle regeneration pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP10, SLC9A8, and RPL35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRP10 grouped by Myoblast fusion involved in skeletal muscle regeneration-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LRP10 →	-0.770	-1.106	.003	.003	3	5
SKIN	SLC9A8 →	-0.607	-1.210	.001	.001	3	5
OESOPHAGUS	RPL35 →	+0.551	+1.214	<.001	.004	3	4
OESOPHAGUS	NANS →	+0.952	+1.371	.001	.002	3	4
OVARY	INIP →	+0.663	+1.209	<.001	.005	3	4
OVARY	SPSB1 →	-1.035	-0.943	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRP10 by Myoblast fusion involved in skeletal muscle regeneration activity — SKIN

Explore this box plot interactively →