Myoblast fusion involved in skeletal muscle regeneration

Across TCGA cell cohorts, RNA activity of the Myoblast fusion involved in skeletal muscle regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD9, PTGFRN, and FANK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast fusion involved in skeletal muscle regeneration activity versus CD9 in LARGE_INTESTINE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD9 →	+1.638	+1.233	.005	.001	3	5
BLOOD_Leukemia	PTGFRN →	+3.815	+1.731	.005	.008	1	6
LUNG_NSCLC_LUAD	FANK1 →	+1.319	+0.912	.003	.006	3	4
LUNG_NSCLC_LUAD	DDR1 →	+1.542	+1.076	.004	<.001	3	4
LUNG_NSCLC_LUAD	PRR13 →	-0.634	-0.831	.009	.003	3	4
OVARY	UTP18 →	-0.856	-1.318	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014905 vs CD9 — LARGE_INTESTINE

Explore this scatter interactively →