Myotube cell development

Across TCGA patient cohorts, RNA activity of the Myotube cell development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, SRRM2_S1320, and TNS2_S102, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myotube cell development activity versus KANK2 in BRCA (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KANK2 →	+0.366	+0.027	.002	<.001	3	5
HNSC	SRRM2_S1320 →	-0.201	-0.054	<.001	.001	3	5
GBM	TNS2_S102 →	+0.400	+0.036	<.001	.004	3	5
GBM	TRIM28_S697 →	-0.858	-0.049	<.001	<.001	3	5
BRCA	RSU1 →	+0.369	+0.032	<.001	<.001	3	4
BRCA	SH3BGRL2 →	+0.462	+0.023	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014904 vs KANK2 — BRCA

Explore this scatter interactively →