Myotube cell development

Across TCGA patient cohorts, RNA activity of the Myotube cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEC, PRRX1, and INHBA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myotube cell development activity versus PLEC in LUAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLEC →	+0.512	+0.219	<.001	<.001	3	5
BRCA	PRRX1 →	+1.203	+0.426	<.001	.002	3	4
BRCA	INHBA →	+0.807	+0.320	<.001	<.001	3	4
LSCC	EMP3 →	+0.667	+0.569	<.001	<.001	3	4
LUAD	DAB2 →	+0.427	+0.263	<.001	<.001	3	4
LSCC	RRAS →	+0.533	+0.582	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014904 vs PLEC — LUAD

Explore this scatter interactively →