Myotube cell development

Across TCGA cell cohorts, RNA activity of the Myotube cell development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A20, UBL3, and PER1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A20 grouped by Myotube cell development-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC25A20 →	-0.594	-1.006	.002	.004	3	4
BREAST	UBL3 →	-1.144	-0.879	<.001	.001	3	4
SOFT_TISSUE	PER1 →	+1.546	+1.264	<.001	.005	3	4
BLOOD_Leukemia	RERE →	+1.254	+1.153	.001	.004	3	4
BLOOD_Leukemia	USP6NL →	+1.771	+1.379	.001	<.001	3	4
OVARY	BTBD18 →	-0.036	-1.178	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A20 by Myotube cell development activity — CNS

Explore this box plot interactively →