Myotube cell development

Across TCGA cell cohorts, RNA activity of the Myotube cell development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP10, MRM3, and MRPL12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myotube cell development activity versus DUSP10 in BONE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DUSP10 →	+2.404	+0.300	<.001	.003	3	6
SOFT_TISSUE	MRM3 →	-0.743	-0.333	.008	.002	3	5
LIVER	MRPL12 →	-0.868	-0.348	.002	<.001	3	5
OVARY	DHODH →	-0.958	-0.447	<.001	.006	3	5
OESOPHAGUS	LRRC58 →	-0.792	-0.306	.009	.002	3	4
KIDNEY	FAM20C →	+2.318	+0.433	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014904 vs DUSP10 — BONE

Explore this scatter interactively →