Myotube differentiation

Across TCGA patient cohorts, RNA activity of the Myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, TAGLN, and TPM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myotube differentiation activity versus FN1 in BRCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FN1 →	+1.139	+0.277	.001	.008	3	5
BRCA	TAGLN →	+0.768	+0.241	.001	.002	3	5
HNSC	TPM2 →	+1.470	+0.190	.005	.005	2	5
OV	TIMP3 →	+1.158	+0.576	.001	.001	2	5
BRCA	COL8A1 →	+1.371	+0.362	<.001	.002	3	4
PDAC	LINC01615 →	+0.493	+0.160	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014902 vs FN1 — BRCA

Explore this scatter interactively →