Myotube differentiation

Across TCGA cell cohorts, RNA activity of the Myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHMP5, BEND7, and TRIM36, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHMP5 grouped by Myotube differentiation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CHMP5 →	-0.555	-1.639	.001	<.001	3	4
PANCREAS	BEND7 →	+1.527	+1.026	.001	.009	3	4
KIDNEY	TRIM36 →	-0.828	-1.032	.002	.009	3	4
URINARY_TRACT	CIAO2A →	-1.013	-1.730	.001	<.001	2	4
URINARY_TRACT	CENPW →	-0.851	-1.334	.003	<.001	3	3
SKIN	ENO3 →	+0.910	+0.907	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHMP5 by Myotube differentiation activity — BLOOD_Lymphoma

Explore this box plot interactively →