Myotube differentiation

Across TCGA cell cohorts, RNA activity of the Myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRM3, SLC25A22, and SAAL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myotube differentiation activity versus MRM3 in BLOOD_Leukemia (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MRM3 →	-0.453	-0.162	.008	.006	2	7
LUNG_SCLC	SLC25A22 →	-0.870	-0.223	.002	.004	3	5
URINARY_TRACT	SAAL1 →	-0.896	-0.260	.001	.008	3	5
CNS	NAT10 →	-0.737	-0.279	.003	.006	3	5
KIDNEY	MRPS23 →	-0.883	-0.373	<.001	.006	3	5
SKIN	NLE1 →	-0.612	-0.272	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014902 vs MRM3 — BLOOD_Leukemia

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