Muscle hypertrophy

Across TCGA patient cohorts, RNA activity of the Muscle hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISLR, SERPINF1, and IGFBP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle hypertrophy activity versus ISLR in OV (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ISLR →	+1.070	+0.185	.003	.005	3	8
GBM	SERPINF1 →	+1.261	+0.223	<.001	.003	3	7
GBM	IGFBP7 →	+1.617	+0.318	<.001	.003	3	7
UCEC	SGIP1 →	+1.125	+0.191	<.001	.002	3	7
CCRCC	SVEP1 →	+1.100	+0.163	<.001	.003	3	7
GBM	LTBP2 →	+1.956	+0.309	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014896 vs ISLR — OV

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