Striated muscle atrophy

Across TCGA patient cohorts, RNA activity of the Striated muscle atrophy pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZFYVE9, TRPM2_S38, and TYMP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle atrophy activity versus ZFYVE9 in OV (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZFYVE9 →	-0.643	-0.080	.009	.004	3	5
PDAC	TRPM2_S38 →	+0.661	+0.046	<.001	.004	3	5
PDAC	TYMP →	+0.385	+0.049	<.001	<.001	3	5
CCRCC	JUNB →	+0.375	+0.041	<.001	<.001	3	5
BRCA	FES →	+0.330	+0.072	.001	.001	3	5
GBM	FMNL1 →	+0.386	+0.064	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014891 vs ZFYVE9 — OV

Explore this scatter interactively →