Striated muscle atrophy

Across TCGA patient cohorts, RNA activity of the Striated muscle atrophy pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEG3, GPR34, and IL16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle atrophy activity versus MEG3 in PDAC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MEG3 →	+0.470	+0.811	.006	.001	3	5
HNSC	GPR34 →	+0.589	+0.609	<.001	<.001	3	4
LSCC	IL16 →	+0.594	+0.692	.003	.003	3	4
HNSC	ACTA2-AS1 →	+0.468	+0.641	.004	.002	3	4
LSCC	ADA2 →	+0.621	+0.553	<.001	.004	3	4
PDAC	SLC25A14 →	+0.252	+0.622	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014891 vs MEG3 — PDAC

Explore this scatter interactively →