Striated muscle atrophy

Across TCGA cell cohorts, RNA activity of the Striated muscle atrophy pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOP53, HERC6, and AMH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOP53 grouped by Striated muscle atrophy-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NOP53 →	-0.784	-0.985	<.001	<.001	3	4
CNS	HERC6 →	+1.149	+1.128	.001	<.001	3	4
OESOPHAGUS	AMH →	-1.883	-0.410	.003	.005	3	4
OESOPHAGUS	GUK1 →	+0.574	+0.443	.004	.004	3	4
LUNG_SCLC	ZSWIM5 →	-2.209	-1.681	.002	.003	3	3
LUNG_SCLC	ULK1 →	-0.847	-1.295	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOP53 by Striated muscle atrophy activity — BREAST

Explore this box plot interactively →