Muscle atrophy

Across TCGA patient cohorts, RNA activity of the Muscle atrophy pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCDC28A, AGFG2, and GATM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle atrophy activity versus CCDC28A in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CCDC28A →	+0.272	+0.067	<.001	<.001	3	5
GBM	AGFG2 →	+0.383	+0.067	<.001	.001	3	5
UCEC	GATM →	+0.686	+0.085	.001	.001	2	6
UCEC	PLEKHA7 →	+0.308	+0.069	.007	.009	3	5
GBM	NT5C →	+0.263	+0.053	<.001	.004	3	5
GBM	PCTP →	+0.280	+0.078	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014889 vs CCDC28A — PDAC

Explore this scatter interactively →