Muscle atrophy

Across TCGA cell cohorts, RNA activity of the Muscle atrophy pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP14, NOP53, and CMPK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARP14 grouped by Muscle atrophy-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PARP14 →	+1.430	+1.703	.006	<.001	3	5
BREAST	NOP53 →	-0.690	-0.841	.001	.002	3	5
BREAST	CMPK2 →	+1.157	+0.850	.009	.009	3	5
PANCREAS	TRIOBP →	+0.836	+1.113	.007	.001	3	4
PANCREAS	C19orf73 →	-0.504	-1.125	<.001	.001	3	4
SOFT_TISSUE	C17orf97 →	+1.016	+0.528	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP14 by Muscle atrophy activity — LARGE_INTESTINE

Explore this box plot interactively →