Muscle atrophy

Across TCGA cell cohorts, RNA activity of the Muscle atrophy pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAK3, MAP3K21, and ZNF606, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle atrophy activity versus JAK3 in OESOPHAGUS (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	JAK3 →	+1.002	+1.442	.006	.001	3	3
BREAST	MAP3K21 →	-1.156	-0.200	.004	.001	3	2
LARGE_INTESTINE	ZNF606 →	-2.077	-1.474	.007	<.001	3	2
BREAST	PARP3 →	-1.409	-0.254	.001	.001	3	2
OESOPHAGUS	PLIN3 →	+1.602	+1.703	.002	<.001	3	2
OESOPHAGUS	ENTPD1 →	+0.456	+1.464	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014889 vs JAK3 — OESOPHAGUS

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