Striated muscle adaptation

Across TCGA patient cohorts, RNA activity of the Striated muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PER2, RBM33, and CCDC93, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle adaptation activity versus PER2 in ESCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	PER2 →	+0.868	+0.043	<.001	<.001	3	20
UVM	RBM33 →	+0.673	+0.033	<.001	<.001	3	20
UVM	CCDC93 →	+0.714	+0.036	<.001	<.001	3	19
ESCA	KMT2C →	+0.753	+0.053	<.001	<.001	3	19
LAML	HDAC4 →	+0.959	+0.050	<.001	<.001	3	19
UVM	NR2C2 →	+0.850	+0.037	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014888 vs PER2 — ESCA

Explore this scatter interactively →