Striated muscle adaptation

Across TCGA patient cohorts, RNA activity of the Striated muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3IL1, MAP3K3, and CXCL12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle adaptation activity versus RAB3IL1 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAB3IL1 →	+0.650	+0.543	<.001	<.001	3	6
UCEC	MAP3K3 →	+0.451	+0.443	.002	.004	3	5
HNSC	CXCL12 →	+1.299	+1.168	<.001	<.001	3	5
GBM	FBLN2 →	+0.939	+0.140	<.001	.002	3	4
GBM	AURKA →	-0.783	-0.182	<.001	.001	3	4
HNSC	CRYAB →	+1.278	+0.784	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014888 vs RAB3IL1 — UCEC

Explore this scatter interactively →