Striated muscle adaptation

Across TCGA cell cohorts, RNA activity of the Striated muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSN, CAST, and RAB2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle adaptation activity versus GSN in BLOOD_Leukemia (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSN →	+2.869	+0.398	<.001	.001	3	6
LUNG_NSCLC_LUAD	CAST →	+1.130	+0.630	<.001	.009	3	5
LUNG_SCLC	RAB2A →	+0.838	+0.931	<.001	.002	3	5
LUNG_NSCLC_LUAD	S100A13 →	+1.476	+0.701	.005	.004	3	4
SOFT_TISSUE	GBP3 →	+2.451	+0.322	.005	.002	3	4
LARGE_INTESTINE	RTN2 →	+0.982	+0.316	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014888 vs GSN — BLOOD_Leukemia

Explore this scatter interactively →